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Publication Abstract:
Authors: Tan PC, Yow CM, Omar SZ
Objective: To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG).
Methods: Patients with HG were randomized at hospitalization to 20 mg oral pyridoxine thrice daily or to placebo. Intravenous rehydration, metoclopramide and oral thiamine were also administered. Metoclopramide and thiamine were continued for 2 weeks after discharge. Rehospitalization for HG in the 2-week study period was ascertained, vomiting was recorded by diary, and nausea was evaluated with a 10-point visual analogue scale (VAS) at enrolment, after hospital discharge and on week 1 and 2 reviews.
Results: Ninety-two women were included in the analysis. The rehospitalization rate was 37.5 versus 21.1% (relative risk 1.8, 95% confidence interval 0.9-3.7, p = 0.14) for pyridoxine and placebo, respectively. Daily vomiting episodes after discharge were not different (mean ± SD): 1.9 ± 2.4 versus 1.4 ± 1.1, p = 0.28 during week 1 and 1.4 ± 1.3 versus 1.4 ± 1.6, p = 0.98 during week 2. Repeated-measures analysis of variance showed no difference in the nausea visual analogue scale (p = 0.59).
Conclusion: The use of oral pyridoxine in conjunction with metoclopramide during the inpatient stay and during the 2 weeks after hospital discharge for hyperemesis gravidarum did not improve the rehospitalization rate, the vomiting frequency or the nausea score. Larger studies need to be done.
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Publication Abstract:
Multivariate models were developed for the simultaneous spectrophotometric determination of copper (II), nickel (II) and zinc (II) in water with 1-(2-thiazolylazo)-2-naphthol as chromogenic reagent in the presence of Triton X-100. To overcome the drawback of spectral interferences, principal component regression (PCR) and partial least square (PLS) multivariate calibration approaches were applied. Performances were validated with several test sets, and their results were then compared.In general, no significant difference in analytical performance between PLS and PCR models. The root mean square error of prediction (RMSEP) using three components for Cu2+, Ni2+ and Zn2+ were 0.018, 0.010, 0.011 ppm, respectively. Figures of merit such as sensitivity, analytical sensitivity, limit of detection (LOD) were also estimated. High reliability was achieved when the proposed procedure was applied to simultaneous determination of Cu2+, Ni2+ and Zn2+ in synthetic mixture and tap water.
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Is locally advanced colon cancer always a
contraindication to curative Straight Laparoscopic
resection? |
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Dr. Law Chee Wei
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Publication Abstract:
Introduction:
The presence of a large palpable colonic malignancy
suggesting a locally advanced tumour used to represent absolute
contraindication to the laparoscopic approach because of technical
difficulties. We report our experience with the straight laparoscopic
anterior resection of a palpable sigmoid colon cancer.
Material and Methods:
A 60 year old male was presented with 8 cm
diameter left iliac fossa mass and altered bowel habit. CT scans
showed sigmoid colon tumour with no clear plane between the
tumour and anterior abdominal wall. Colonoscopy revealed stenosing
sigmoid colon tumour. A straight laparoscopic anterior resection was
performed in Lloyd Davis position. A lateral to medial approach was
undertaken using a 4-port technique with placement of ports at subumbilical,
right iliac fossa, right and left hypochondrium. Sigmoid
colon was dissected off anterior abdominal wall together with cuff of
abdominal wall musculature. Inferior mesentery artery was ligated near the origin using EndoGIA. Specimen was retrieved via extended
left iliac fossa wound before colo-rectal anastomosis was established
using DST EEA-31.
Results:
We present the straight laparoscopically approach of an
anterior resection for locally advanced sigmoid colon tumour. No
intraoperative or postoperative complications were detected. After surgery,first bowel movement occurred on the second day and the
patient was fit for diacharge on fifth day. Due to social reasons, he
stayed till ninth postoperative day. However, there was no issue
during this period. Histologically findings revealed pT3N2 moderately
differentiated adenocarcinoma with clear resection margin.
Conclusions:
Straight laparoscopic anterior resection in patients with
locally advanced sigmoid colon tumour is feasible with a fast
recovery and a short hospital stay. Long term follow up is necessary
to evaluate recurrence rate of this procedure.
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Publication Abstract:
APPROACHES TO SUBTANCE ABUSE AMONG CHILDREN IN INDIA
Abstract: Substance abuse among the children is one of the Nation’s most serious health problems and is associated with numerous social ills, causing more deaths, illnesses, and disabilities than any other preventable health condition. It is also associated with a large number of social ills, such as prenatal drug exposure, family violence, child abuse, crime, neighborhood gang activity, and unemployment. This article highlights the various factors influencing the substance abuse and the ways and means for the different approaches to this problem. The article highlights the measures to prevent drug abuse among the children and adolescents. And finally briefly discusses on the need for the treatment for the substance abuse.
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Publication Abstract:
Thong YL, Messer HH, Zain RB, Saw LH, Yoong LT
Progressive replacement resorption following delayed replantation of avulsed teeth has proved to be an intractable clinical problem. A wide variety of therapeutic approaches have failed to result in the predictable arrest of resorption, with a good long-term prognosis for tooth survival. Bisphosphonates are used in the medical management of a range of bone disorders and topically applied bisphosphonate has been reported to inhibit root resorption in dogs. This study evaluated the effectiveness of a bisphosphonate (etidronate disodium) as an intracanal medicament in the root canals of avulsed monkey teeth, placed before replantation after 1 h of extraoral dry storage. Incisors of six Macaca fascicularis monkeys were extracted and stored dry for 1 h. Teeth were then replanted after canal contamination with dental plaque (negative control) or after root canal debridement and placement of etidronate sealed in the canal space. A positive control of calcium hydroxide placed 8-9 days after replantation was also included. All monkeys were sacrificed 8 weeks later and block sections were prepared for histomorphometric assessment of root resorption and periodontal ligament status. Untreated teeth showed the greatest extent of root resorption (46% of the root surface), which was predominantly inflammatory in nature. Calcium hydroxide treated teeth showed the lowest overall level of resorption (<30% of the root surface), while the bisphosphonate-treated group was intermediate (39%). Ankylosis, defined as the extent of the root surface demonstrating direct bony union to both intact and resorbed root surface, was the lowest in the untreated control group (15% of the root surface), intermediate in the calcium hydroxide group (27%) and the highest in the bisphosphonate group (41%). Bony attachment to the tooth root was divided approximately equally between attachment to intact cementum and to previously resorbed dentin. Overall, bisphosphonate resulted in a worse outcome than calcium hydroxide in terms of both root resorption and ankylosis.
Dent Traumatol. 2009 Aug;25(4):386-93.
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Featured Abstract : 422 |
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